Odorant and flavorant

ABSTRACT

The preparation and use as odorant and/or flavorant of 2,6,10,10-tetramethyl-1-oxa-spiro-[4,5]-decan-7-one (I).

FIELD OF THE INVENTION

This invention relates to the field of odorants and flavorants.

SUMMARY OF THE INVENTION

The present invention relates to a novel odorant and/or flavoring substance. More particularly, the invention is concerned with the aforementioned compound, 2,6,10,10-tetramethyl-1-oxa-spiro-[4,5]-decan-7-one, of the formula: ##STR1## a process for the manufacture thereof and odorant and/or flavoring compositions containing same. The invention is also concerned with a method of imparting an odor and/or flavor to materials using said compound of formula I or said compositions.

Formula I hereinbefore is intended to collectively embrace (8) stereoisomers, namely the 4 diastereomers or 4 enantiomer pairs. ##STR2##

According to the process provided by the present invention, the compound of formula I hereinbefore is manufactured by

(a) cyclising 3-(3-hydroxybutyl)-2,4,4-trimethylcyclohex-2-enone, or

(b) isomerising 6,7-epoxy-2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-decane, or

(c) oxidising 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-decan-7-ol or a compound of the general formula ##STR3## wherein R represents a hydrogen atom or an alkyl, cycloalkyl or 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-7-decyl group, or

(d) reducing 6-methylene-2,10,10-trimethyl-1-oxa-spiro[4,5]-decan-7-one.

The term "alkyl" used herein means, in particular, a C₁₋₆ -alkyl group such as the methyl, ethyl, propyl and like groups. Suitable cycloalkyl groups are, in particular, the cyclopentyl and cyclohexyl groups.

Table 1 hereinafter gives a detailed synopsis of the manufacture of the compound of formula I by embodiments (a) to (d) of the present process, and also indicates convenient practical approaches to the corresponding starting materials:

                                      Table 1                                      __________________________________________________________________________      ##STR4##                                                                       ##STR5##                                                                       ##STR6##                                                                       ##STR7##                                                                       ##STR8##                                                                       ##STR9##                                                                 

Table 2 hereinafter indicates materials and reagents as well as convenient and preferred reaction parameters for the individual embodiments of the process:

                                      Table 2                                      __________________________________________________________________________     Process                                                                        embodi-                                                                        ment Reaction type                                                                          Agent     preferred  Solvent  Temperature                         __________________________________________________________________________     (a)  Acid catalysis                                                                         Protonic acids                                                                            p-Toluenesulphonic                                                                       Aliphatic or                                                                            e.g.                                             Lewis acids                                                                              acid       aromatic                                                            perchloric acid                                                                           (chlorinated)                                                                           -10°- 100°                                   sulphuric acid                                                                            hydrocarbons                                                        hydrochloric acid                                                                         ether                                                               boron trifluoride                                                              hydrate                                                                        ˜etherate                                         (b)  Acid isomeris-                                                                         Weak Lewis acids                                                                         Mg-salts,  Aprotic solvents,                                                                       e.g.                                     ation             LiClO.sub.4, etc                                                                          (chlorinated)                                                                           -30°- 100°                                              hydrocarbons,                                                                  ether                                        (c)  Chromic acid,                                                                          Jones, Sarett*,                                                                          [see L. F. Fieser,                                           chromate,                                                                              Kiliani, Collins,                                                                        M. Fieser, "Reagents                                                                               e.g.                                     bichromate                                                                             Corey, Cornforth*,                                                                       for Organic Synthesis"                                                                             ca. -20°-                         oxidation                                                                              Brown oxidation +,                                                                       John Wiley Inc.     30° C.                                    etc       pages 142-147 (I),                                                             54-56 (III), 95-97                                                             (IV), 141-142 (V)]                                      (d)  e.g. catalytic                                                                         Pt, Pd, Ni                                                                               [see R. L. Augustine,                                                                     e.g. alcohols                                                                           e.g.                                     hydrogenation     "Catalytic Hydrogen-                                                                        esters,                                                                               R.T.                                                       ation"       cyclic and                                                        M. Dekker, New York                                                                         acyclic                                                           1965]        hydrocarbons,                                                                  ether                                      __________________________________________________________________________      *not for compound V                                                            + e.g. literature reference 3) p. 11                                     

Insofar as they are not known, the starting materials required for the individual embodiments of the process (see Table 1) can be prepared as follows:

                                      Table 3                                      __________________________________________________________________________     Step in                                                                        Table 1                                                                            Reaction type                                                                          Agent        for example                                                                              Solvent  Temperature                        __________________________________________________________________________     (e) Isomerisation                                                                          Aluminium derivatives                                                                       diethylethoxy-                                                                           Aliphatic or                                                                            20°-150° C.          aluminium,                                                                         aromatic hydro-                                                                                     dialkylalumnium-                                                                         carbons,                                    tetramethylpiper-                                                                  alcohols (e.g.                                                                                      idides, aluminium                                                                        isopropanol)                                                         alcoholates (Al                                                                triisopropylate)                                                  Lewis acids  BF.sub.3 as the etherate                                                                 Aliphatic or                                                         or hydrate                                                                               aromatic hydro-                                                                         -40°-+40° C.                                            carbons (e.g.                                                                  dichloromethane)                                        Protonic acids                                                                              Sulphonic acids                                                                          Hydrocarbons                                                                            0°-100° C.                                    such as p-toluene-                                                                       (benzene,                                                                               20°-50° C.                                    sulphonic acid,                                                                          toluene)                                                             benzenesulphonic                                                               acid                                                  (f) Hydrogenation                                                                          Catalysts    Pd, Pt, Rh, Ru                                                                           Esters, hydro-                                                                          0°-50° C.                                     with or without                                                                          carbons  (20° C.)                                             carrier (aluminium                                                                       alcohols                                                             oxide, CaCo.sub.3,                                                             BaSO.sub.4)                                                                    preferred:                                                                     Pt        ethanol                                                              Pd (CaCO.sub.3)                                                                          ethanol                                     (g) Oxidation                                                                              Activated pyrolusite,                                                                       Jones oxidation,                                                                         (Chlorinated)                                                                           20°-100° C.                      Ag.sub.2 CO.sub.3 on Celite,                                                                chromate oxidation                                                                       hydrocarbons                                                                            -10°-30° C.                      or according to (c)                                                                         according to                                                                             acetone  -10°-35° C.                      for example  Brown 3)  ether                                                   →(see c)                                                                             hexane                                                (h) Hydroboration                                                                          (R).sub.2 BH Literature refer-                                                 B.sub.2 H.sub.6                                                                             ences                                                                          1) 2)                                                 (i) Oxidation                                                                              H.sub.2 O.sub.2 /NaOH                                                                       Literature refer-  ˜0°-R.T.                                       ences                                                                          1) 2)                                                 (k) Photo-  O.sub.2, air                                                       see: A. Schonberg                                                                          0°-50° C.                                                oxidation                                                                              h√(tungsten lamps                                                                    "Preparative       (20° C.)                                UV-high pressure burner)                                                                    Organic Photo-                                        senstiser                                                                          chemistry",                                                                            (haematoporyphyrin,                                                                         2. Edtn.                                                          rose Bengal, etc.)                                                                          Springer Verlag                                                                1968                                                  (1) Reduction                                                                              Sulphites (e.g.                                                                             Thiosulphates(e.g. -10° -35° C.                     Na.sub.2 SO.sub.3)                                                                          Na.sub.2 S.sub.2 O.sub.3)                                         bisulphites (e.g.                                                              NaHSO.sub.3)                                                                   dithionites (e.g.                                                              Na.sub.2 S.sub.2 O.sub.4 ) etc.                                    __________________________________________________________________________

Literature

(1) H. C. Brown, Hydroboration, Benjamin Publ. N.Y. (1962) 4-38, 106-11

(2) ibid. 67-72

(3) H. C. Brown, JACS, 2951 (1961)

The compound of formula I has particular organoleptic properties, on the basis of which it is excellently suited as an odorant and/or flavouring substance.

The invention is therefore also concerned with a method of imparting an odour and/or flavour to materials, which method comprises applying to said materials or incorporating therein a flavour-imparting amount of the compound of formula I in practically pure form or in the form of mixtures (with the exception of mixtures containing the natural compound of formula I) or of an odorant and/or flavouring composition containing same.

The expression "practically pure" is used herein to mean, in particular, the compound of formula I which is free from accompanying substances which are present in addition to the compound of formula I in natural extracts. As practically pure compound I in the scope of the present invention there is to be understood, for example, the synthetically manufactured compound of formula I.

The natural mixtures containing I must, therefore, be excluded, since in the course of the foregoing work it has been found that Ia, Ib, Ic and Id are contained at a ratio of 2:1:2:1 in a quantity of 0,2-0,3% by weight in the osmanthus absolute.

The compound of formula I has a fine, woody, olfactory nuance reminiscent of dried fruits and tobacco. In addition, there are associated aspects of the odour of cedarwood oil, patchouli oil and armois oil. The compound of formula I can therefore be used, for example, for the perfuming or flavouring of products such as cosmetics (soaps, salves, powders etc), detergents or foodstuffs, luxury consumables and drinks, the compound preferably not being used alone but rather in the form of compositions which contain other odorant or flavouring substances. Such odorant or flavouring compositions containing the compound of formula I and their production in a manner known per se (the addition of the compound of formula I to known odorant or flavouring compositions or the admixture of the compound of formula I with natural or synthetic compounds or mixtures suitable as ingredients of odorant or flavouring compositions) likewise form part of the present invention.

On the basis of its very natural notes, the compound of formula I is especially suitable for the modification of known compositions such as those of the rose and chypre type, those having a generally flowery trend, and tobacco. Thus, it is very well suited, for example, for combination with green notes such as, for example, with neroli notes, as well as with flower notes such as, for example, rose, narcissus, Easterbell, broom.

It has eventually been found that the compounds I may also be used in the substitution of essential oils, such as e.g. sage oil, cedarwood oil, armois oil. In this use, there are obtained, especially, elegant round-off effects.

The concentration of the compound of formula I can vary within wide limits depending on the purpose of use; for example, between about 0.01 wt.% in the case of detergents and about 15 wt.% in the case of alcoholic solutions. In perfume bases or concentrates, the concentration can, of course, also be higher.

As a flavouring substance, the compound of formula I can be used, for example, for the production or improvement, intensification, enhancement or modification of fruit or berry aromas in foodstuffs (yoghurt, sweet goods etc), in luxury consumables (tobacco etc) and drinks (lemonades etc).

The pronounced flavour qualities of the practically pure, and especially of the synthetically manufactured, compound of formula I enables it to be used in low concentrations. A suitable range is 0.01 ppm-100 ppm, preferably 0.1 ppm-10 ppm, in the finished product (i.e. the aromatised foodstuff, luxury consumable or drink).

Table 4 hereinafter illustrates some effects which can be achieved with the compound of formula I.

                  Table 4                                                          ______________________________________                                         Aroma    Amount          Effect                                                ______________________________________                                         Raspberries                                                                             ppm             Emphasising the                                                in the finished product                                                                        velvet-woody note of                                           0.1-30 ppm,     the raspberries,                                               especially 0.5-4 ppm                                                                           giving the impression                                                          of very ripe fruits                                   Apricots ppm             Impression of dried                                            in the finished product                                                                        apricots                                                       0.1-40 ppm,                                                                    expecially 0.5-6 ppm                                                  Damsons  ppm             Analogous to apricots                                 Plums    in the finished product                                                                        (impression of dry                                    Figs     0.1-40 ppm,     fruits)                                               Grapes   expecially 0.5-6 ppm                                                  ______________________________________                                    

The compound of formula I can be mixed with the ingredients used for flavouring compositions or added to such flavours in the usual manner. Among the flavours contemplated according to the present invention there are to be understood flavouring compositions which can be diluted or dispersed in edible materials in a manner known per se. They can be converted according to methods known per se into the usual forms of use such as solutions, pastes or powders. The products can be spray-dried, vacuum-dried or lyophilised.

For the production of such usual forms of use there come into consideration, for example, the following carrier materials, thickening agents, flavour-improvers, spices and auxiliary ingredients:

Gum arabic, tragacanth, salts or brewers' yeast, alginates, carrageens or similar absorbants; indoles, maltol, dienals, spice oleoresins, smoke flavours; cloves, diacetal, sodium citrate; monosodium glutamate, disodium inosine-5'-monophosphate (IMP), disodium guanosine-5-phosphate (GMP); or special flavouring substances, water, ethanol, propyleneglycol, glycerine.

The following Examples illustrate the process provided by the present invention:

EXAMPLE 1

To a mixture, cooled to 0° C., of 19.4 g (0.1 mol) of 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-dec-6-ene of the formula ##STR10## and 19.7 g of anhydrous sodium acetate in 150 ml of chloroform were added dropwise with simultaneous stirring 20.9 g (0.11 mol) of 40% peracetic acid in such a manner that the temperature was always between 5° C. and 9° C. Subsequently, the mixture was stirred for a further 2 hours at room temperature, the sodium acetate was removed by filtration, the clear solution was washed three times with water, three times with soda solution and once again with water, dried over sodium sulphate and concentrated. There were obtained 18.4 g of crude product which contained the epoxides of the formulae ##STR11## in the ratio 9:1.

15.5 g (0.074 mol) of the epoxide of formula IIIa (having a purity of greater than 98%), obtained from the previously described isomer mixture by column-chromatographical separation, were dissolved, together with 7.5 g (0.037 mol) of aluminium isopropylate, in 45 ml of isopropanol. The vessel containing this mixture was placed in an oil-bath at 170° C. and about nine-tenths of the isopropanol was distilled off via a 20 cm Vigreux column. The residual viscous mass was subsequently stirred for 2 hours at this oil-bath temperature (=a temperature of the mixture of 130°-135° C.), then cooled down to room temperature, treated with 60 ml of 30% sodium hydroxide solution, again heated to 50° C., held at this temperature for 5 minutes, further cooled down, treated with 100 ml of water and extracted with ether. The ether phase was washed three times with water, dried and concentrated. There were obtained 14.0 g of a colourless oil which, in accordance with chromatographical analysis, contained the allyl alcohol of the formula ##STR12## in a purity of greater than 95%.

NMR: 0.85 and 0.93 (6H, 2s); 1.19 (3H, d, J=6 cps); 3.92 (1H, m); 4.47 (1H, m); 4.93 and 5.19 (2H, 2m) δ ppm,

MS: m/e=210 (M⁺, 9), 153 (64), 141 (69), 125 (35), 111 (24), 101 (33), 95 (28), 85 (91), 70 (34), 55 (69), 43 (87), 41 (100).

13.4 g (0.064 mol) of the allyl alcohol of formula VIIa were dissolved in 50 ml of ethanol, treated with 150 mg of platinum-IV oxide and subsequently hydrogenated at normal pressure until saturated (the hydrogen consumption amounted to 1.53 liters). After filtration and concentration, there remained 13.2 g of crude product consisting, in accordance with gas-chromatographical analysis, of two components in the ratio of 2:1. Subsequent column chromatography of the crude product on a 30-fold amount of silica gel using hexane/ether (5:1) for the elution yielded 7.9 g of the alcohol of the formula ##STR13## of melting point 74°-74.5° C.

NMR: 0.85 and 0.93 (6H, 2s); 1.00 (3H, d, J=6 cps); 1.21 (3H, d, J=6 cps); 3.90 (1H, m); 3.93 (1H, m) δ ppm

MS: m/e=212 (M⁺, 2); 141 (100), 126 (19), 112 (21), 95 (6), 85 (28), 70 (13), 69 (13), 55 (29), 43 (30), 41 (35).

Using hexane/ether (1:1) for the elution there were obtained 3.9 g of a further purified alcohol to which can be assigned formula IVb according to spectral data. This alcohol has a melting point of 76.5°-77° C. ##STR14##

NMR: 0.86 and 0.96 (6H, 3s); 1.05 (3H, d, J=6 cps); 1.20 (3H, d, J=6 cps); 3.58 (1H, m); 4.20 (1H, m) δ ppm

MS: 212 (M⁺, 4), 141 (100), 126 (13), 112 (15), 85 (21), 70 (7), 57 (14), 55 (17), 43 (17), 41 (19).

To a solution, cooled to 0° C., of 6.85 g (0.032 mol) of the alcohol of formula IVa in 30 ml of ether were allowed to drop in in the course of 5 minutes with intensive cooling and intensive stirring 30 ml of an aqueous solution, cooled to 0° C., of 9.80 g (0.032 mol) of sodium dichromate dihydrate and 8.9 g of concentrated sulphuric acid in such a manner that the temperature was between 0° C. and 3° C. Subsequently, the mixture was allowed to react for 5 minutes at 0° C. to 3° C., treated with 100 ml of ether, the ether phase was washed three times with water, three times with soda solution and again with water, dried over sodium sulphate and concentrated. There were obtained 5.1 g of a crystalline crude product which, in accordance with gas-chromatographical analysis, showed a purity of greater than 93%. It had a melting point of 89° C. after recrystallisation from pentane. According to spectral data, this product is the compound of formula Ia.

IR: 1705, 1080, 1065, 1020, 1001, 981, 965, 908 cm⁻¹

NMR: 1.00 and 1.25 (6H, 2s); 1.05 (3H, d, J˜6 cps); 1.24 (3H, d, J˜6 cps); 2.38 (2H, m); 3.11 (1H, q, J˜6 cps); 4.10 (1H, m) δ ppm

MS: m/e=210 (M⁺, 24), 154 (55), 139 (40), 126 (100), 112 (85), 99 (22), 83 (17), 70 (25), 56 (35), 43 (56), 41 (57).

The compound of formula Ia has a woody-cedarous odour which is accompanied by a slight amber note.

The oxidation of 3.42 g (0.016 mol) of the alcohol of formula IVb, carried out in an analogous manner, gave 2.6 g of a crystalline crude product which consisted of the spiro compound of formula Ib. The purity was greater than 93%. A sample recrystallised from pentane had a melting point of 49° C.

IR: 1710, 1089, 1070, 975, 913, 730 cm⁻¹

NMR: 0.99 and 1.20 (6H, 2s); 1.06 (3H, d, J˜6 cps); 1.17 (3H, d, J˜6 cps); 2.65 (1H, q, J˜6 cps); 4.16 (1H, m) δ ppm

MS: m/e=210 (M⁺, 17), 154 (47), 139 (43), 126 (80), 112 (100), 99 (20), 83 (19), 70 (33), 55 (35), 43 (41), 41 (58).

The compound of formula Ib has a woody-cedarous odour which is reminiscent of patchouli leaf oil and of dried fruits.

EXAMPLE 2

19.4 g (0.1 mol) of 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-dec-6-ene of the formula ##STR15## were epoxidised in a manner analogous to that described in Example 1. The crude product obtained (20.0 g) consisted essentially of two components in the ratio of 3:2 according to gas chromatography. After their pure isolation by column chromatography, these components were shown to be the epoxides of the formulae ##STR16##

7.82 g (0.037 mol) of the epoxide of formula IIIc were subjected to rearrangement with aluminium isopropylate in a manner analogous to that described in Example 1. There were obtained 7.7 g of crude product which consisted to greater than 95% of the allyl alcohol of the formula ##STR17## An analytical sample showed, after previous bulb-tube distillation, the following spectral data:

NMR: 0.83 and 0.93 (6H, 2s); 1.20 (3H, d, J=6 cps); 4.06 (1H, m); 4.52 (1H, m); 4.95 and 5.13 (2H, 2m)

MS: m/e=210 (M⁺, 8), 153 (45), 141 (52), 125 (30), 111 (21), 101 (29), 95 (25), 85 (79), 70 (29), 55 (69), 43 (86), 41 (100).

The hydrogenation of 7.0 g (0.033 mol) of the allyl alcohol of formula VIIb led to two saturated alcohols in the ratio of 2:1. The subsequent column-chromatographical separation [hexane/ether (5:1)] of the crude product gave 4.0 g of the pure alcohol of the formula ##STR18##

NMR: 0.91 and 1.00 (6H, 2s); 1.01 (3H, d, J=6 cps); 1.20 (3H, d, J=6 cps); 4.0 (2H, 2m); δ ppm

MS: m/e=212 (M⁺, 1), 141 (100), 126 (15), 112 (28), 85 (30), 70 (15), 57 (34), 55(43), 43 (45), 41 (59).

With hexane/ether (1:1) there were eluted 2 g of a second alcohol which, after recrystallisation from ether, had a melting point of 89° C. This alcohol has the formula ##STR19##

NMR: 0.91 (6H, 2s); 0.98 (3H, d, J=6 cps); 1.22 (3H, d, J=6 cps); 3.46 (1H, m); 4.02 (1H; m) δ ppm

MS: m/e=212 (M⁺, 2); 141 (100), 126 (5), 112 (18), 85 (16), 70 (5), 57 (14), 55 (16), 43 (17), 41 (20).

7.1 g (0.034 mol) of the mixture of alcohols of formulae IVc and IVd, obtained by hydrogenating the allyl alcohol of VIIb, were oxidised with sodium dichromate in the manner previously described. There were obtained 6.3 g of a crystalline crude product which, in accordance with gas-chromatographical analysis, consisted of two components in the ratio of 2:1. By recrystallisation from pentane there could be obtained 2.5 g of the pure main component, the compound of formula Ic, which was eluted first in the gas-chromatogram. This compound had a melting point of 74°-74.5° C.

IR: 1702, 1081, 1060, 1050, 1020, 1001, 960, 875 cm⁻¹

NMR: 0.99 (3H, d, J˜6 cps); 1.25 (3H, d, J˜6 cps); 1.02 and 1.30 (6H, 2s); 2.35 (2H, m); 2.91 (1H, q, J˜6 cps), 4.10 (1H, m); δ ppm

MS: m/e=210 (M⁺, 7), 154 (47), 139 (40), 126 (44), 112 (100), 99 (11), 83 (12), 70 (23), 56 (40), 43 (32), 41 (50).

The compound of formula Ic has a woody odour with slight green side-notes.

By chromatography of the remaining mother liquor on a 40-fold amount of silica gel there were obtained, by elution with hexane/ether (10:1), 1.3 g of the compound of formula Id which, after recrystallisation from pentane, had a melting point of 64° C.

IR: 1715, 1089, 1080, 1030, 1010, 975, 879 cm⁻¹

NMR: 0.97 and 1.14 (6H, 2s); 0.98 (3H, d, J˜6 cps); 1.19 (3H, d, J˜6 cps); 2.62 (1H, q, J˜6 cps); 4.00 (1H, m); δ ppm

MS: m/e=210 (M⁺, 5), 154 (47), 139 (42), 126 (34), 112 (100), 99 (10), 83 (13), 70 (22), 56 (39), 43 (39), 41 (50).

The compound of formula Id has a woody-cedarous odour which is at the same time reminiscent of patchouli leaf oil and dried fruits.

EXAMPLE 3

70 g (0.36 mol) of 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-dec-6-ene of formulae Xa and Xb (ratio 2:1) were expoxidised according to the procedure described in Examples 1 and 2. The resulting crude product (77 g) consisted of the four isomeric epoxides of formulae IIIa, IIIb, IIIc and IIId in the ratio of ca 9:1:2:1 in accordance with gas-chromatographical analysis. This crude epoxide mixture was directly subjected to the rearrangement with aluminium isopropylate, there being obtained, after working-up and distillation, 43 g of a product (yield 57% based on the starting material) of boiling point 87°-89° C./0.15 mm Hg which contained for the most part the two allyl alcohols of formulae VIIa and VIIb. The subsequent hydrogenation using ethanol as the solvent and platinum-IV oxide as the catalyst led to a mixture of the 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-decan-7-ols of formula IV which was directly oxidised as the crude product (42 g) according to the procedure described earlier. There were obtained 37 g of crude product which consisted of the four isomers of 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-decan-7-one of formulae Ia, Ib, Ic and Id in the ratio of 4:2:2:1 in accordance with gas-chromatographical analysis.

Distillation of the crude product over a 20 cm Widmer column gave 31 g (41% based on starting material of formula Xa+Xb) as an olfactorily satisfactory product of boiling point 86°-91° C./0.06 mm Hg which possessed a woody-cedarous odour and was reminiscent of patchouli leaf oil and dried fruits.

EXAMPLE 4

A solution of 4.26 g (0.03 mol) of boron trifluoride dietherate in 4 ml of tetrahydrofuran was allowed to drop in in the course of 30 minutes to a solution of 10.5 g (0.054 mol) of the compound of formula Xa and 1.13 g (0.03 mol) of sodium borohydride in 25 ml of anhydrous tetrahydrofuran in such a manner that the temperature did not exceed 25° C. After stirring at room temperature for 16 hours, the mixture was cautiously treated with a solution of 2.16 g (0.054 mol) of sodium hydroxide in 8 ml of water and then in the course of 30 minutes with simultaneous cooling of the vessel 7.6 g (0.067 mol) of 30% hydrogen peroxide were added dropwise in such a manner that the temperature did not exceed 30° C. For completion of the reaction, the mixture was stirred for 2 hours at room temperature and then extracted with ether. The ether phase was washed with water, dried and concentrated. There were obtained 11.1 g of crude product which consisted to greater than 90% of the alcohol of formula IVb in accordance with gas-chromatographical analysis.

7.1 g of the crude alcohol of formula IVb were oxidised with sodium dichromate as described earlier. Bulb-tube distillation of the crude product (6.5 g) gave 5.1 g (67% yield based on starting material) of the crystalline compound of formula Ib (purity greater than 95%) which was contaminated with very little compound of formula Ia. A sample recrystallised from pentane had a melting point of 49° C. The same reaction sequence was likewise used on 10.5 g (0.054 mol) of 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-dec-6-ene of formula Xb (purity greater than 90%). After recrystallisation from pentane, there were finally obtained 4.3 g of the compound of formula Id (56% yield based on starting material B; purity greater than 98%). This compound had a melting point of 64° C.

EXAMPLE 5

The reaction sequence chosen for the selective preparation of the compound of formula Ib or Id (Example 4) was used on 194 g (1 mol) of the mixture of 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-dec-6-ene of formulae Xa and Xb (2:1). There were obtained 107 g of an olfactorily satisfactory mixture of the compounds of formulae Ib and Id (in the ratio of ca 2:1) of boiling point 85°-91° C./0.06 mm Hg. The yield was 51%. This isomer mixture has a woody-cedarous odour which at the same time is reminiscent of patchouli leaf oil, tobacco and distinctly of dried fruits.

EXAMPLE 6

A suspension of 5.5 g (0.145 mol) of sodium borohydride in 260 ml of ether was treated with 0.9 g of dry powdered zinc chloride, stirred for 2 hours at room temperature and then added to a solution of 77.6 g (0.4 mol) of 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-dec-6-ene of formulae Xa and Xb in 10 ml of cyclohexane. Over a period of 1 hour there was allowed to drop in a solution of 21 g (0.148 mol) of boron trifluoride dietherate in 125 ml of ether in such a manner that the temperature did not exceed 25° C. The mixture was stirred for 16 hours at room temperature, cautiously treated with 50 ml of water and there were allowed to drop in with good stirring and ice-cooling over a period of 30 minutes 450 ml of an aqueous solution of 110 g (0.369 mol) of sodium dichromate dihydrate and 80 ml of concentrated sulphuric acid in such a manner that the temperature did not exceed 30° C. After stirring for an additional 2 hours at room temperature, the mixture was extracted with ether, the ether phase was washed three times with water, three times with soda solution and again with water, dried over sodium sulphate and concentrated.

Distillation of the crude product (80.4 g) over a 20 cm Widmer column gave, in addition to 34 g of starting material, 27 g of a mixture of compounds of formulae Ib and Id in the ratio of 2:1; boiling point 84°-91° C./0.07 mm Hg; yield 32% based on starting material.

The following Examples illustrate odorant and/or flavouring compositions provided by the present invention:

EXAMPLE A

    ______________________________________                                         Flowery composition Parts by weight                                            ______________________________________                                         Hydroxycitronellal  400                                                        Linalyl acetate     200                                                        Geraniol extra      200                                                        Phenylethyl-phenyl acetate                                                                         110                                                        Hexenyl salicylate   40                                                        Cyclamen aldehyde    20                                                        Eugenol extra        20                                                                            990                                                        ______________________________________                                    

When there are added to this flowery and somewhat soap-like base 10 parts of the compound of formula I, then there appears an unexpected effect in that the composition takes on a suave, exotic, narcotic and very natural note in the direction of ylang-ylang.

EXAMPLE B

    ______________________________________                                         Rose base           Parts by weight                                            ______________________________________                                         Phenylethyl-phenyl acetate                                                                         500                                                        Geraniol extra      300                                                        α-Ionone       60                                                        Linalool (synthetic)                                                                                50                                                        Cinnamic alcohol (synthetic)                                                                        40                                                        Geranyl acetate      20                                                        Versalide (7-acetyl-1,1,4,4-                                                   tetramethyl-7-ethyl-1,2,3,4-                                                   tetralin)            20                                                                            990                                                        ______________________________________                                    

When there are added to this conventional rose base 10 parts of the compound of formula I, then the resulting composition acts lighter, rounder and less sweet. From a rather harsh rose base there results a light, mild rose base. The composition acts harmoniously and much rounder.

EXAMPLE C

    ______________________________________                                         Perfume base in the direction of tobacco                                                              Parts by weight                                         ______________________________________                                         α-Irisone        200                                                     o-Tert.butyl-cyclohexyl acetate                                                                       200                                                     Musk ketone            100                                                     Sandalwood oil         100                                                     Hexylcinnamaldehyde    100                                                     Styrallyl acetate      60                                                      Methyl dihydrojasmonate                                                                               40                                                      Coumarin               20                                                      Benzoin resinoid       20                                                      Isobutylquinoline (10% in propylene-                                           glycol)                20                                                      Lavender oil           20                                                      Vetiver oil Bourbon    20                                                      Melilotus absolute colourless                                                                         10                                                      Galbanum oil concentrated                                                                             10                                                                             920                                                     ______________________________________                                    

The compound of formula I binds especially well with the aforementioned components. The natural tobacco effect results at first by addition of 80 parts of the compound of formula I. From a general chypre composition having a sweet-dusty character there results a very fine cedarous-amber like composition with emphasis on the tobacco-wood note.

EXAMPLE D

    ______________________________________                                         Chypre base          Parts by weight                                           ______________________________________                                         Bergamotte oil       200                                                       α-Hexylcinnamaldehyde                                                                         200                                                       Linalool extra       200                                                       Phenylethyl alcohol  100                                                       Methyl dihydrojasmonate                                                                              60                                                       Sandalwood oil        60                                                       Oak moss absolute decolorised                                                                        40                                                       Vetiver oil Bourbon   20                                                       Styrallyl acetate     20                                                                            900                                                       ______________________________________                                    

When there are added to this rather cologne-like chypre composition 100 parts of the compound of formula I, then there results a very pleasant soft and warm wood-chypre composition. The somewhat sharp hesperide note is suppressed; in its place there appears a rich sandal-vetiver note.

EXAMPLE E

    ______________________________________                                         Fruity base           Parts by weight                                          ______________________________________                                         Propyleneglycol       240                                                      Hydroxycitronellal    200                                                      Dimethylbenzylcarbinyl butyrate                                                                      200                                                      Bergamotte oil        100                                                      Methyl dihydrojasmonate                                                                              100                                                      Fructone (2-methyl-1,3-dioxolan-2-                                             ethyl acetate)        100                                                      Maltylisobutyrate      20                                                      β-Methyl-β-phenylglycidic acid                                       ethyl ester (10% in propylene-                                                 glycol)                20                                                                            980                                                      ______________________________________                                    

When there are added to this fresh fruit base 20 parts of the compound of formula I, then this is altered in a distinct manner in the direction of dried fruit (fig). The resulting composition acts markedly powerful and complete.

EXAMPLE F

    ______________________________________                                         Green base            Parts by weight                                          ______________________________________                                         Linalyl acetate (synthetic)                                                                          300                                                      α-Hexylcinnamaldehyde                                                                          240                                                      Benzyl salicylate     200                                                      Methyl dihydrojasmonate                                                                              100                                                      Basilicum oil          60                                                      Linalyl anthranilate   40                                                      Cyclal (2,4-dimethyl-3-cyclohexen-                                             1-carboxaldehyde) (10% in                                                      propyleneglycol)       20                                                      p-Menthane-8-thiol-3-one                                                                              10                                                      Galbanum oil          10                                                                             980                                                      ______________________________________                                    

With the addition of only 20 parts of the compound of formula I to the green, herb-like base the character thereof is totally altered in the direction of a fresh spring bloom (narcissus).

EXAMPLE G

    ______________________________________                                                          Parts by weight                                               Apricot aroma      A         B                                                 ______________________________________                                         γ-Valerolactone                                                                             0.1 g     0.1 g                                             Ethyl vanillin     0.5 g     0.5 g                                             Vanillin           1.0 g     1.0 g                                             Butyric acid geranyl ester                                                                        2.0 g     2.0 g                                             Propionic acid geranyl ester                                                                      4.0 g     4.0 g                                             Raspberry ketone   8.0 g     8.0 g                                             Rum ether          12.0 g    12.0 g                                            Orange oil 10-fold concentrated                                                                   13.5 g    13.5 g                                            C-14-aldehyde      28.0 g    28.0 g                                            Butyric acid ethyl ester                                                                          28.5 g    28.5 g                                            Ketone I (10% in alcohol)    10.0 g                                            Propylene glycol   902.4 g   892.4 g                                                              1000.0 g  1000.0 g                                          ______________________________________                                    

Addition of the compound of formula I to the foregoing conventional apricot aroma A brings about a distinct odoriferous alteration in that there appears in the resulting composition B a woody-fruity note. Regarding taste, there is ascertainable, in particular, a fruity-woody note, the resulting aroma being strongly reminiscent of dried apricots.

EXAMPLE H

    ______________________________________                                                           Parts by weight                                              Raspberry Aroma    A          B                                                ______________________________________                                         Palmitic acid ethyl ester                                                                         0.05 g     0.05 g                                           Geraniol           0.2 g      0.2 g                                            Methylionone       0.6 g      0.6 g                                            Ethyl vanillin     1.0 g      1.0 g                                            Valeric acid amyl ester                                                                           1.0 g      1.0 g                                            Acetic acid benzyl ester                                                                          2.0 g      2.0 g                                            C-16-aldehyde      2.5 g      2.5 g                                            Formic acid ethyl ester                                                                           4.0 g      4.0 g                                            Acetic acid amyl ester                                                                            6.0 g      6.0 g                                            Butyric acid ethyl ester                                                                          6.0 g      6.0 g                                            Acetic acid isobutyl ester                                                                        23.0 g     23.0 g                                           Acetic acid ethyl ester                                                                           33.5 g     33.5 g                                           Ketone I (10% in alcohol)     10.0 g                                           Propyleneglycol    920.15 g   910.15 g                                                            1000.0 g   1000.0 g                                         ______________________________________                                    

Addition of the compound of formula I to the foregoing composition A, a conventional raspberry aroma, alters the methylionate note in an odoriferously advantageous manner in that there appears in the composition B a fruity-woody note. Regarding flavour, there is ascertainable a distinct woody-fruity note which is characteristic of raspberries. 

What is claimed is:
 1. Synthetically manufactured 2,6,10,10-tetramethyl-1-oxa-spiro[4,5]-decan-7-one. 